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KMID : 1147220190200040091
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Journal of Biomedical and Translational Research
2019 Volume.20 No. 4 p.91 ~ p.98
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Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model
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Jeong Kang-Jin
Kang Phil-Yong
Lee Hwal-Yong
Son Hee-Chang
Park Sung-Hyun
Choi Won-Seok
Koo Bon-Sang
Jeon Chang-Yeop
Baek Seug-Ho
An You-Jung
Kim Hyun-Kuk
Kim Sung-Soo
Park Jun-Kyu
Bae In-Ho
Park Dae-Sung
Shim Jae-Won
Kim Jae-Un
Kim Nan-Yeol
Kim Sun-Uk
Lim Kyung-Seob
Jeong Myung-Ho
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Abstract
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This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.
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KEYWORD
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cholesterol, balloon angioplasty, coronary stents, percutaneous coronary intervention, restenosis
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